All functions |
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Add the genotype information for the list of pruned SNVs into the Profile GDS file |
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Append information associated to ld blocks, as indexes, into the Population Reference SNV Annotation GDS file |
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Append information associated to blocks, as indexes, into the Population Reference SNV Annotation GDS file |
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Append information associated to blocks, as indexes, into the Population Reference SNV Annotation GDS file |
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Add the information about the unrelated patients to the Reference GDS file |
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Append information about the 1KG samples into the Profile GDS file |
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Select the optimal K and D parameters using the synthetic data and infer the ancestry of a specific profile |
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Select the optimal K and D parameters using the synthetic data and infer the ancestry of a specific profile |
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Run a k-nearest neighbors analysis on one specific profile |
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Run a k-nearest neighbors analysis on a subset of the synthetic dataset |
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Project synthetic profiles onto existing principal component axes generated using the reference 1KG profiles |
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Project specified profile onto PCA axes generated using known reference profiles |
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Run a PCA analysis and a K-nearest neighbors analysis on a small set of synthetic data using all 1KG profiles except the ones used to generate the synthetic profiles |
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Calculate the AUROC of the inferences for specific values of D and K using the inferred ancestry results from the synthetic profiles. |
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Generate accuracy graph |
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Generate accuracy graph |
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Create the Profile GDS file(s) for one or multiple specific profiles using the information from a RDS Sample description file and the 1KG GDS file |
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The known super population ancestry of the demo 1KG reference profiles. |
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The PCA results of the demo 1KG reference dataset for demonstration purpose. Beware that the PCA has been run on a very small subset of the 1KG reference dataset and should not be used to call ancestry inference on a real profile. |
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The PCA result of demo synthetic profiles projected on the demo subset 1KG reference PCA. |
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The pedigree information about a demo profile called 'ex1'. |
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Estimate the allelic fraction of the pruned SNVs for a specific profile |
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Generate the GDS file that will contain the information from Reference data set (reference data set) |
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Generate the filter SNP information file in RDS format |
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Adding the phase information into the Reference GDS file |
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Adding the phase information into the Reference GDS file |
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Extract the specified column from the 1KG GDS 'sample.ref' node for the reference profiles (real ancestry assignation) |
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Extract the from the 1KG GDS 'sample.ref' node for the reference profiles (real ancestry assignation) |
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Merge the genotyping files per chromosome into one file |
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Identify genetically unrelated patients in GDS Reference file |
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Identify genetically unrelated patients in GDS Reference file |
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Run most steps leading to the ancestry inference call on a specific DNA profile |
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Run most steps leading to the ancestry inference call on a specific RNA profile |
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A small |
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A small |
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Prepare the pedigree file using pedigree information from Reference |
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Add information related to the synthetic profiles (study and synthetic reference profiles information) into a Profile GDS file |
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Compute the list of pruned SNVs for a specific profile using the information from the Reference GDS file and a linkage disequilibrium analysis |
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Run most steps leading to the ancestry inference call on a specific exome profile |
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Run most steps leading to the ancestry inference call on a specific RNA profile |
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Random selection of a specific number of reference profiles in each subcontinental population present in the 1KG GDS file |
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Random selection of a specific number of reference profiles in each subcontinental population present in the 1KG GDS file ( same as select1KGPop but the function doesn't need gds object as parameters but the file name of the referenceGDS ) |
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A small |
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Generate a VCF with the information from the SNPs that pass a cut-off threshold |
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Group samples per subcontinental population |
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Generate synthetic profiles for each cancer profile and 1KG reference profile combination and add them to the Profile GDS file |