A short collection of published gene signatures that primarily focuses on PDAC classification for patient-derived organoids (PDO). While the signatures are accurate, this list is mainly compiled for demonstration purposes.
data(signaturesDemo)a list containing one entry per signature:
"Classical": a
vector of gene names associated to the PDAC Patient-derived
Organoid (PDO) Classical signature as published in Tiriac et al 2018
"Basal-like": a
vector of gene names associated to the PDAC Patient-derived
Organoid (PDO) Basal-like signature as published in Tiriac et al 2018
Tiriac H, Belleau P, Engle DD, et al. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov. 2018;8(9):1112-1129. doi:10.1158/2159-8290.CD-18-0349
The PDAC patient-derived organoids (PDO) classical and basal-like signatures are associated with this publication:
Tiriac et al. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov. 2018 Sep;8(9):1112-1129. doi: 10.1158/2159-8290.CD-18-0349. Epub 2018 May 31. PMID: 29853643; PMCID: PMC6125219.
runSubtypingBimodal for the classification of heterogeneous biological samples based on gene signature lists using a mixture of two normal distributions
getGeneSignaturesNames for the names of the available and ready-to-use gene signature lists
getGeneSignatures for the available and ready-to-use gene signature lists
## Load the published signature gene list
data(signaturesDemo)