Demonstration gene signatures for PDAC subtyping

A short collection of published gene signatures that primarily focuses on PDAC classification for patient-derived organoids (PDO). While the signatures are accurate, this list is mainly compiled for demonstration purposes.

Usage

data(signaturesDemo)

Format

a list containing one entry per signature:

• "Classical": a vector of gene names associated to the PDAC Patient-derived Organoid (PDO) Classical signature as published in Tiriac et al 2018

• "Basal-like": a vector of gene names associated to the PDAC Patient-derived Organoid (PDO) Basal-like signature as published in Tiriac et al 2018

Source

Tiriac H, Belleau P, Engle DD, et al. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov. 2018;8(9):1112-1129. doi:10.1158/2159-8290.CD-18-0349

Details

The PDAC patient-derived organoids (PDO) classical and basal-like signatures are associated with this publication:

Tiriac et al. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov. 2018 Sep;8(9):1112-1129. doi: 10.1158/2159-8290.CD-18-0349. Epub 2018 May 31. PMID: 29853643; PMCID: PMC6125219.

See also

• runSubtypingBimodal for the classification of heterogeneous biological samples based on gene signature lists using a mixture of two normal distributions

• getGeneSignaturesNames for the names of the available and ready-to-use gene signature lists

• getGeneSignatures for the available and ready-to-use gene signature lists

Examples

## Load the published signature gene list
data(signaturesDemo)